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Paper Information

Title: 

EFFECT OF GABA ON PERFUSION PRESSURE OF MESENTERIC BED IN DIABETIC RATS AND ROLE OF ENDOTHELIUM

Type: POSTER
Author(s): FARSI L.*,KESHAVARZ MANSOUR,SOLTANI N.,HASANIN PARISA
 
 *DEPARTMENT OF PHYSIOLOGY SCHOOL OF MEDICINE, MASHAD UNIVERSITY OF MEDICAL SCIENCES, MASHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Diabetes has profound negative effects on the function of arteries and arterioles throughout the body. Diabetes-related dysfunction of resistance vessels is associated with arterial hypertension and vascular occlusive diseases. Vasorelaxant agents may have a role in prevention or control of diabetic cardiovascular complications. Gamma Aminobutyric Acid (GABA) has demonstrated to cause vasorelaxation. Little attention has been paid to the impact of GABA on vascular complication of diabetes. Regarding controversial findings, the present study was designed to determine i) the vasorelaxatory effect of GABA on diabetic vessels and ii) the role of endothelium in GABA-induced vasorelaxation. Diabetes was induced by a single tail injection of streptozotocin. Eight weeks later, superior mesenteric arteries of control and diabetic animals were isolated and perfused according to the McGregor method. Prepared vascular beds were constricted with phenylephrine to induce 70–75% of maximal constriction. GABA (1 to 50μM) was added into the medium and perfusion pressure was then recorded. Mesenteric bed baseline perfusion pressure in intact and denuded endothelium of diabetic groups was higher than controls. In all groups, relaxant response to GABA in mesenteric bed appeared. Although diabetes induction did not change mesenteric bed response to GABA, denuded vessels showed a severe reduced response to GABA in both control and diabetic animals. This data suggests that GABA can induce endothelium-dependent vasorelaxation in normal and diabetic rats.

 
Keyword(s): DIABETES, MESENTERIC VASCULAR BED, ENDOTHELIUM DYSFUNCTION, GABA
 
 
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