Paper Information

Title:  METABOLIC CHANGES AFTER BRIEF EXPOSURE TO ISOFLURANE, DIETHYL ETHERAND CO2 IN MALE RATS
Type: POSTER
Author(s): ZARDOUZ H.*,ROSTAMKHANI F.,ZARIN GHALAM MOGHADAM JALAL,FARAJI SHAHRIVAR F.
 
 *DEPARTMENT OF PHYSIOLOGY, FACULTY OF MEDICINE, AND NEUROSCIENCE RESEARCH CENTER, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

The effects of anesthetic agents on blood corticosterone level as an indicator of stress response and also some other metabolic parameters have been the subject of several studies. In the present study, the effects of brief exposure to inhaled anesthetics-isoflurane, diethyl ether and CO2-on plasma corticosterone, glucose and insulin concentrations have been investigated in male Wistar rats. Animals were divided into groups of control and experiment. The control group had no exposure to anesthetics. The experimental groups of animals were briefly exposed to either diethyl ether (4 min), isoflurane (2 min), or CO2 (1 min). Blood samples were taken by retro-orbital-puncture method. Diethyl ether caused no significant change in plasma corticosterone and insulin levels whereas increased the plasma concentrations of glucose in the experimental group as compared to the control group. On the other hand, in the rats of the experimental group CO2 decreased plasma corticosterone but increased plasma glucose levels significantly compared with the controls. Whereas, isoflurane anesthesia caused no significant change in plasma corticosterone, glucose and insulin concentrations in the experimental group. In conclusion, brief exposure to either diethyl ether or CO2 can result in significant changes in plasmacorticosterone and/or glucose concentrations, whereas isoflurane caused no significant change in the plasma levels of those parameters. Thus, isoflurane is the best choice in experiments investigating metabolic factors and would help to solve the problem of the metabolic changes which may be induced by the application of the anesthetic agents.

 
Keyword(s): ISOFLURANE, CO2 ANESTHESIA, DIETHYL ETHER, CORTICOSTERONE, GLUCOSE, INSULIN
 
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