Paper Information

Title: 

EFFECT OF CABERGOLINE ON LIVER FUNCTION TESTS IN ADULT MALE RATS

Type: POSTER
Author(s): AZARNOUSH ZH.*,MOKHTARI MOKHTAR,SHARIATI MEHRDAD,KAZEMI MOHAMMAD REZA
 
 *DEPARTMENT OF BIOLOGY, ISLAMIC AZAD UNIVERSITY, KAZEROUN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Nowadays, research for finding side effects of chemicals drugs is essential. In this research, the side effects of cabergoline, a drug used for treatment of Parkinson’s disease and hyperprolactinemia, were examined on liver function tests. Forty male Wistar rats were used in five groups (n=8) including control receiving none; sham receiving distilled water; and experimental groups receiving 0.1, 0.5, or 1 mg/kg of cabergoline subcutaneously for 14 days. At the end of experiments, blood samples were taken from all animals, and liver function tests including albumin, total protein, ALT, AST, ALP, and bilirubin were measured using auto-analyzer. Results show no significant changes in ALT and AST in experimental groups. In addition, ALP and bilirubin showed a significant decrease in all experimental groups. In groups receiving 0.5 or 1mg/kg cabergoline, albumin and total protein showed a significant decline. Cabergoline exerts a significant decreasing effect on hepatic function leading to a decline in bilirubin, total protein and albumin levels.

 
Keyword(s): CABERGOLINE, LIVER FUNCTION TEST, MALE RAT
 
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