Paper Information

Title: 

EFFECTS OF TWO DOSES OF PROPYLTIOURACIL (PTU) ON THYROID GLAND IN RAT

Type: POSTER
Author(s): SHIRAZI BEHFAR M.*,YOUSEFVAND NAMDAR,AZADBAKHT MEHRI
 
 *DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCES, UNIVERSITY OF RAZI, KERMANSHAH, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Thyroid dysfunction is considered as one of the most important endocrinopathies. Insufficient level of thyroid hormones produces a clinical condition called hypothyroidism. In this study, we investigated the effects of propyltiouracil (PTU)- induced hypothyroidism on thyroid gland. Twenty-one young male Wistar rats were divided into three groups. The control group received drinking water; two induced hypothyroidism groups were treated for 60 days with 1 or 10mg PTU in 100ml drinking water daily (low and high doses groups respectively). At the end of treatment duration, animals were anesthetized; blood samples and thyroid gland obtained; and serum levels of T3 and T4 were determined with radioimmunoassay. Thyroid gland was removed, weighed, then fixed and processed according to the routine technique. Our results showed that the serum level of T4 in treatment groups was lower than control group. The lowest amount was seen in the high dose group (p<0.001). Macroscopic studies showed that weight of thyroid gland was increased in treatment groups compared to control (p<0.001). Morphometry assay for thyroid tissue in treatment groups demonstrated that of thyroid tissue was disrupted. The size and number of follicles were reduced in low and high dose groups (p<0.01 and p<0.001, respectively). PTU can be as an inducer of hypothyroidism at low doses by reduction of thyroid hormones and histological changes in thyroid gland. However, the changes increase, as does the dose of PTU.

 
Keyword(s): HYPOTHYROIDISM, PTU, THYROID GLAND, RAT
 
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