Paper Information

Title: 

GHRELIN (HUNGER HORMONE) AND ITS EFFECTS ON MEAN PLASMA CONCENTRATION OF GROWTH HORMONE WITH DIFFERENT ENERGY LEVEL IN CAMEL

Type: POSTER
Author(s): MOHAMMADI MANSOUR*,KHAZALI H.
 
 *FACULTY OF BIOLOGICAL SCIENCE, SHAHID BEHESHTI UNIVERSITY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Ghrelin is a novel peptide predominantly purified from stomach and identified as an endogenous ligand of growth hormone secretagogue receptor (GHS-R). Ghrelin is a potent growth hormone (GH) regulator and inaddition to actively participating in controlling energy balance; it regulates food intake and appetite. Thus, it can be effective in obesity. The aim of this study was to investigate effect of ghrelin on mean plasma concentration of GH in animals with two different energy levels. In addition, this experiment had not been performed on camels so far. We selected twelve camels randomly and divided them into two equal groups. Each group was fed with different nutrition diets (50% and 100% of energy level). Animals in each group received daily infusion of 8μg/Kg ghrelin for four days via jugular vein. Blood samples were collected for six days (one day before the first ghrelin infusion until one day after the last infusion). Samples were assayed for plasma GH concentration by radioimmunoassay (RIA). Data were analyzed with repeated measure ANOVA and significance level was set at p 0.05. Results demonstrate that ghrelin increased GH among all animals throughout the infusion period but this enhancement was more sensible in animals with 100% energy level intake. This shows the influence of ghrelin and the direct relation between nutrition and GH concentration in the body.

 
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