Paper Information

Title: 

ROLE OF ENDOGENUS GHRELIN ON ACTH CONCENTRATION IN IMMATURE CAMELS FED DIFFERENT LEVELS OF ENERGY REQUIREMENTS

Type: POSTER
Author(s): RASHEDI R.*,KHAZALI H.
 
 *FACULTY OF BIOLOGICAL SCIENCE, SHAHID BEHESHTI UNIVERSITY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

In 1999, a new group of neuropeptids called ghrelin were discovered. Ghrelin is an orexigenic peptide hormone which is secreted mainly from the stomach, rises in peripheral plasma before meals, and is implicated in stimulating hunger. Recent researches indicate that ghrelin affects positive energy balance and food intake and regulates action of different systems. The immunereactivity of ghrelin are has shown its presence in high amounts in hypothalamus and parts of the brain responsible for the regulation of the HPA axis; therefore, ghrelin could be quite effective on the secretion of corticotropins. These secretions are influenced by the various neurotransmitters of hypothalamus. However, the effect of the ghrelin on ACTH concentrations before puberty has never been examined in semi ruminant animals. The purpose of the present research was to determine the effect of ghrelin on ACTH secretion before puberty in camels. Twelve camels were randomly divided into two groups. Animals in each group were fed either 50% or 100% of energy content in diet for 2 weeks. After 2 weeks, camels received 8μg ghrelin/kg into their jugularvein for 4 days. Blood samples were collected from jugular vein 30 minutes after injection of ghrelin. Plasma was assayed for plasma ACTH concentrations by RIA. The results of this experiments indicated that the injection of ghrelin in animals receiving 50% or 100% of dietary energy intake significantly increased the mean plasma concentrations of ACTH in pubertal camels.

 
Keyword(s): GHRELIN, ADERNOCORITICOTROPIN RELEASING HORMONE, IMMATURE CAMEL
 
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