Paper Information

Title: 

EFFECT OF PUNICA GRANATUM FLOWER EXTRACT, ON BLOOD GLUCOSE, INSULIN AND BLOOD PRESSURE IN FEMALE RAT'S MODEL OF PREDIABETES

Type: POSTER
Author(s): ESHAGHI N.*,BAHARI Z.,AHANGARPOUR A.
 
 *DEPARTMENT OF PHYSIOLOGY, PHYSIOLOGY RESEARCH CENTER & DIABET RESEARCH CENTER, SCHOOL OF MEDICINE, JUNDISHAPOUR MEDICAL SCIENCES UNIVERSITY OF AHWAZ, AHWAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Today about 6% of the population in the age group of 20-79 years, are suffering from diabetes mellitus in Iran; its prevalence is increasing as in other developing countries. Since to use the Punica granatum flower (PGF) extract in traditional medicine for decrease blood glucose and lipid. We decided to study the effect of this plant in female rat's model of prediabetes.
30 adult female Wistar rats weighting 150-170(g) were used. After prediabetes induced by sucrose 32% in drinking water for 6 weeks, the animals were randomly divided into 5 groups: control, sucrose induced, aqueous (400mg/kg) and hydro-alcoholic (300 and 500 mg/kg) extract of PGF extract of fruit. 48 hours after the last injection, blood was collected from heart, serum was dissented and blood glucose, insulin, fasting insulin resistance index (FIRI) and blood pressure were determined.
Weight in sucrose induced and PGF extract treatment groups were not changed. Blood pressure, insulin, glucose and FIRI in sucrose induced-extract of PGF in comparisons with control group were significantly increased.
The results of this study were shown increases blood pressure, glucose, insulin and FIRI in sucrose induced-PGF extract in comparisons with control group. Thus, the PGF animals displayed characteristics typical of insulin resistance and it suggest that the investigator can do more research on this plant.

 
Keyword(s): PUNICA GRANATUM FLOWER, BLOOD GLUCOSE, INSULIN, BLOOD PRESSURE
 
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