Paper Information

Title: 

THE EFFECT OF ESTROGEN ON THE ACCELERATION WOUND HEALING IN DIABETIC RATS

Type: POSTER
Author(s): KHAKSARI S.*,KESMATI MAHNAZ,REZAEI ANAHITA,RASEKH A.A.R.,AKHOUNDZADEH RAZIEH
 
 *DEPARTMENT OF BIOLOGY, SCHOOL OF SCIENCES, SHAHID CHAMRAN UNIVERSITY, AHVAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Impaired wound healing in diabetic patients, it is a major clinical problem, which it is associated with significant morbidity and mortality. By considering on the positive effect of estrogen in neoangiogenesis, reepithelialization and cell proliferation, in this research the possible effect of estrogen on wound healing in diabetic male rats were investigated.
This study was desighned on male wistar rats (body weight 200±20 g) which were divided to 2 groups (normal and diabetic). Each group was divided into 3 subgroups (control, sham and test). Circular full- thicknesses wound with a diameter of 1.5 cm were created on the backs of streptozotocin (stz)-induced diabetic and intact rats. Daily 10 μg/sc of estradiol benzoate was administered to test subgroup for 28 days and sham subgroup was injected with placebo. The control subgroup didn’t receive anything. Wound size and pathology evaluation was assessed at 3, 5, 7, 14, 21, 28 days. in macroscopic study, there was delay in healing diabetic group in comparison with normal group and since the day seventh wound healing has considerable change in estradiol subgroups in both normal and diabetic rats (p<0.05). In microscopic study, coating tissue reorganization, inflammatory cells, granulation tissue, neoangiogenesis formation surveyed semi-quantities. in all cases estradiol receiving subgroup has showed impressive improvementcomparing to other subgroups (p<0.05).
This research expresses that estrogen can improve the impaired healing of diabetic wounds and this effect related with rate of wound healing and wound structure.

 
Keyword(s): WOUND HEALING, ESTROGEN, DIADETIC RAT, PATHOLOGY
 
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