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Paper Information

Title: 

LOCUS COERULEUS LESIONS & PCOS: ROLE OF THE CENTRAL AND PERIPHERAL SYMPATHETIC NERVOUS SYSTEM IN RAT OVARIAN FUNCTION

Type: POSTER
Author(s): AMINI FATEMEH,ZAFARI ZANGENEH FARIDEH*
 
 *VALI-E-ASR, REPRODUCTIVE HEALTH RESEARCH CENTER, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder associated with ovulatory dysfunction. Autonomic and central nervous systems play important roles in the regulation of ovarian physiology. The noradrenergic nucleus Locus Coeruleus (LC) plays a central role in regulation of the sympathetic nervous system and is synaptically connected to the preganglionic cell bodies of the ovarian sympathetic pathway and its activation is essential to trigger spontaneous or induced LH surges. The aim of this study was to evaluate sympathetic outflow in central (LC lesion) and peripheral pathways (administration of antagonist) in PCO rats.Our objectives in this study were (1) to estimate LC activity (chemical lesion) in rats with estradiol valerate (EV)-induced PCO; (2) to antagonize alpha2a adrenoceptor (with Yohimbine). Our results show that chemical lesion of LC in PCO rats increased estrogen (P<0.001) but had not effect on FSH and LH. Yohimbine also increased only esterogen in estrogen PCO in rat (P<0,001). Rats with EV-induced PCO had an increased sympathetic and HPA-axis activity and our data show that LC lesion and Yohimbine (ip) only increased esterogen.

 
Keyword(s): POLYCYSTIC OVARY SYNDROME (PCOS), LOCUS COERULEUS, SYMPATHETIC NERVOUS SYSTEM, YOHIMBINE
 
 
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