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Paper Information

Title: 

ASPF2, ASPF4, ASPF6 AS IMPORTANT ALLERGENS OF ASPERGILLUS FUMIGATUS FOR DIAGNOSIS OF ABPA IN CYSTIC FIBROSIS PATIENTS

Type: PAPER
Author(s): ASLRAHNAMAI AKBARI N.*,KAZEMI A.,SALEHPOUR A.,NOUKHAHI I.
 
 *DEPT OF IMMUNOLOGY-PARASITOLOGY, FACULTY OF MEDICINE, TABRIZ UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Type of Seminar:  CONGRESS
Sponsor:  IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES
Date:  2007Volume 6
 
 
Abstract: 

Aspergillus fumigatus, a widely distributed sport-bearing fungus, causes multiple diseases in human beings, which include mycotoxicesis, allergic reactions and systemic diseases (invasive aspergillusis) with high mortality rates. Systemic aspergillosis occurs primarily in who have immunodeficiency or immunocompromised, patient with chronic granulomatous, neutropenia, who underline corticosteroid treatments and …. The prevalence of allergic bornchopulmonary aspergillosis (ABPA) has been estimated to be around 1-2% in asthmatics; 0-25% amount patient’s with cystic fibrosis, (CF) even 60% in atopy cystic fibrosis patients has been reported. Attention to high rate of ABPA in CF patients, diagnosis of this allergy, and addling antifungal treatment to protocol of CF patient therapy will be useful to improve the patients.
Method: Many studies have been done among children with cystic fibrosis (CF). Skin test, chest radiographs, evolution of purified recombinant allergens from A. Fumigatus, namely Aspf1, f2, f3, f4, and f6 by using ELISA and a Semi-Automated method (ImmunoCAP).
Results: Level of specific IgE to A.fumigatus is high in 34% of patients with CF, and significantly level of specific IgE to ASP f2, f4, f6 is higher in CF patients with ABPA than non ABPA.
Conclusion: More than 18 Antigen/Allergen of A. fumigatus have been identified. Recent studies have demonstrated that patients with ABPA react to a larger number of the recombinant allergens, but level of IgE specific Asp f2, f4 and f6 are higher than other allergens in sera of these patients. Therefore, these intracellular proteins may be regarded specific marks for ABPA.

 
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