Paper Information

Title: 

EFFECTS OF DIFFERENT DOSES OF ZINC SUPPLEMENTATION ON BLOOD GLUCOSE IN ADULT MALE RATS

Type: POSTER
Author(s): KHOSRAVANI S.*,MOAZEDI A.A.,FATEMI R.,ZADKARAMI M.R.
 
 *BIOLOGY DEPT, SCHOOL OF SCIENCE, SHAHID CHAMRAN UNIVERSITY, AHVAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Zinc is an essential trace element for all forms of life. Zinc plays important roles in growth and development, immune responses, neurological functions and reproduction. One of the major roles of zinc is its antioxidant activity. Increased zinc intake may protect against conditions associated with zinc deficiency such as diabetes. Zinc deficiency is known to be associated with an increased prevalence of coronary artery disease as well as diabetes. Low zinc amounts lead to an abnormal elevation in blood glucose and reduced glucose tolerance in rats. Serum zinc levels are significantly lowers in patients with type I diabetes mellitus (T1DM) than those of healthy subjects. High zinc intake significantly reduced the severity of T1DM in a wellcharacterized streptozotocin- induced diabetes models. The dietary zinc supplementation attenuated hyperglycemia and hyperinsulinemia, suggesting a role for zinc in pancreas function and peripheral tissue glucose uptake. In this research, the effect of two doses of zinc supplement was investigated on blood glucose levels in adult male rats. Zinc chloride was administered by gavage at two doses (30, 100mg/kg/day) for two weeks. Sham group received water for two weeks. Results show that blood glucose was significantly lower in groups receiving zinc chloride (30 or 100mg/kg/day) than control and sham groups (p<0.05). This experiment showed that zinc chloride can lower elevated blood glucose in rats.

 
Keyword(s): DIABETES, ZINC SUPPLEMENTATION, GLUCOSE, STREPTOZOTOCIN, RAT
 
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