Paper Information

Title: 

THE INTERFERING EFFECT OF PIPERINE ON AMNESIC EFFECTS OF MIDAZOLAM AND DIAZEPAM IN MICE

Type: POSTER
Author(s): MAHDIPOUR ELNAZ*,KHALILIAN E.,ZAKER ABBASI M.,MOGHADAMNIA ALI AKBAR
 
 *
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Introduction: The effect of piperine on the central nervous system is not clearly known until now. In this study the interference of piperine on drug induced amnesia in mice was examined by using of step-through passive avoidance learning.
material & methods: 90 male albino mice were examined as 5 groups: G1) received piperine (15mg/kg) for 3 days and after electric shock received midazolam (2.5mg/kg) in fourth day, G2) received piperine for 3 days and diazepam (2.5mg/kg) after shock, G3) saline for 3 days and midazolam after shock, G4) saline for 4 days and diazepam after shock, G5) saline in all 4days as control group. In all groups, the latency period of moving from bright room to dark room in 3 hours, 24 hours and 1 week after shock was studied. Data wereanalyzed with SPSS, by using of Kaplan-meier test.
Results: There wasnt any significant difference between groups in the latency period of moving, 3 hours, 24 hours and 1 week after shock (P<0.05) there was'nt either sig difference between T1, T2 & T3 in each group.

 
Keyword(s): PIPERINE, MICE, MEMORY, ELECTRIC SHOCK
 
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