Paper Information

Title: 

EFFECTS OF DIFFERENT DIETARY OIL ON THE IMMUNOLOGICAL RESPONSES OF FEMALE RAT AFTER LIPOPOLYSACCHARIDE CHALLENG

Type: POSTER
Author(s): ESMAEILI FARZANEH*,MOSHTAGHI KASHANIAN GH.R.
 
 *DEPARTMENT OF PHYSIOLOGY AND PHARMACOLOGY AND PHYSIOLOGY RESEARCH CENTER, SCHOOL OF MEDICINE, KERMAN UNIVERSITY OF MEDICAL SCIENCES, KERMAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Consumption of different unsaturated fatty acids could affect the immune response to oxidative or bacterial challenge. To evaluate the protective effect ofdietary corn or olive oils, following 6 weeks consumption, (25 mg/kg or 210 mg/kg) on immune system of female rats, cytokine production were evaluated following acute lipopolysaccharide (100μg/kg &200μg/kg) challenge.
Serum concentration of INF-
g  (TH1), IL-4 and IL-10 (TH2) were evaluated using ELISA kits, before and after appropriated oil consumption or lipopolysaccharide challenge (time 0, 4 and 24 hours).
Following low dose of LPS challenge, production of IL-4 and IL-10 were higher among the animals that consumed oils (p<0.05) while production of INF-
g was higher following septic shock (p<0.05). These observations suggest that, consumption of corn or olive oil by production of pro-inflammatory cytokines have protective effects in vivo. In addition, these fatty acids might be useful therapies in acute and chronic inflammatory diseases.

 
Keyword(s): CORN OIL, OLIVE OIL, LPS, RAT, IL-4, IL-10 AND INF-γ
 
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