Paper Information

Title:  MONTOUX TEST IN BCG-VACCINATED CHILDREN WITH ASTHMA
Type: SPEECH
Author(s): ALE YASIN S.*,KATIBEH P.,ASADI SAMAN,AMIN REZA
 
 *ALLERGY & IMMUNOLOGY RESEARCH LAB, PEDIATRIC DEPARTMENT, MEDICAL UNIVERSITY OF SHIRAZ
 
Name of Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Type of Seminar:  CONGRESS
Sponsor:  IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES
Date:  2007Volume 6
 
 
Abstract: 

Introduction: Recent studies have proposed a decline in tuberculosis infection is a factor underlying the rising severity and prevalence of atopic disorders in developed countries. There are also conflicting reports on the effect of Bacillus Calmette-Guerin (BCG) vaccination on the subsequent development of atopy and asthma. BCG as the most potent inducer of TH1 is believed to suppress TH2 dependent atopic reaction.
Methods: Trying to prove this hypothesis, in a case-control simple sampled 100 patients below the age of 5, who were known case of asthma with variable severity, received 5-unit intra-dermal tuberculin test. The patients were also BCG - vaccinated at birth. As the control group 100 healthy children previously vaccinated at birth, who were age-adjusted with case group, underwent tuberculin test (PPD) as well. After 48 hours, induction area was measured in two vertical and longitudinal diameters. At the same time, the severity of asthma in the case group was determined (according to the classification of National Institutes of Health, National Institutes of Heart, lung and blood), by asking mothers about the frequencies of night and day symptoms or intervals of attacks. The patients were divided into three groups: mild, moderate and severe groups (mild intermittent and mild persistent groups were classified as one).
Results: In our case group, mean size of PPD skin test response was 1.7mm±2.99 mm but in the control group mean size was 4.42mm ± 3.69mm (p<0.0001). Also in another test we divided our case group into two groups; PPD skin test less than 5mm and more than 5 mm; again with a significant P value.
Conclusion: As a conclusion, patients with definite asthma had a significant weaker response to PPD test. This is indicator of weaker TH1 response in allergic patients, can be proposed that stimulation of TH1- immune system by BCG vaccination at birth can influence subsequent development of allergic diseases dominantly mediated with TH2- Immune system. This may promise a revolution in the future of asthma. Regarding the severity of asthma, no significant evidence supported the relation between severity of asthma and PPD skin test response; it may be explained by dominancy of moderate asthma group.

 
Keyword(s): ASTHMA, MONTOUX TEST, TH1 IMMUNITY
 
Yearly Visit 23  
 
Latest on Blog
Enter SID Blog