Paper Information

Title: 

THE EFFICACY OF THE BIOADHESIVE PATCHES CONTAINING LICORICE EXTRACT IN THE MANAGEMENT OF RECURRENT APHTHOUS STOMATITIS

Type: POSTER
Author(s): KHANIAN M.*,KAZEMI M.T.,REZAEI M.M.,MOTALEBNEZHAD M.,MOGHADAMNIA ALI AKBAR
 
 *DEPARTMENT OF PHARMACOLOGY, BABOL UNIVERSITY OF MEDICAL SCIENCES, BABOL, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

This study evaluated the efficacy of licorice bioadhesive hydrogel patches to control the pain and reduce the healing time of recurrent aphthous ulcer.
This study was carried out in three episodes of ulcers: In the first episode of ulcer, all of 15 patients were asked to record their baseline individual pain level by Visual Analog Scale. In the second and third episodes, comparative and consecutive subjective and objective evaluations of the bioadhesive were done.
The effects of the following variables were investigated: (1) VAS pain score during 5 consequence days, (2) The profile of aphthous ulcers on the days 3 and 5, (3) The time of complete relief of pain and healing of the ulcers, (4) The diameterof the lesions and necrotic zone. A significant reduction in VAS was recorded following application of the licorice patched on the days, 2, 3, 4 & 5 compared to no treatment group (p<0.001). Licorice patches caused a significant reduction in the diameter of inflammatory halo and necrotic center as compared with the placebo group (p=0.03).
According to the results of this study, licorice bioadhesive can be effective in reduction of pain and of inflammatory halo and necrotic center of aphthous ulcers.

 
Keyword(s): RECURRENT APHTHOUS STOMATITIS, LICORICE, BIOPATCH, VAS PAIN SCORE
 
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