Paper Information

Title:  SURVEY ON PREVENTION EFFECT OF MATRICARIA CHAMOMILLA ON WITHDRAWAL SYMPTOMS IN MORPHINE DEPENDENT RATS
Type: POSTER
Author(s): KHABAZ MAHDI*,MOVAFAGHI S.M.,REYHANI B.,SAFARI E.,SHABESTARI ASL A.
 
 *VETERINARY FACULTY, ISLAMIC AZAD UNIVERSITY, TABRIZ BRANCH, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Addiction to opiates such as morphine is one of the major global health problems. Some reports show that Matricaria chamomilla extract contains flavonoids, which exert Benzodiazepine-like activity and inhibited the expression of abstinence syndrome in morphine-dependent animals. To etermined and comparison the effect of Matricaria chamomilla extract injection on morphine withdrawal syndrome signs (MWS) in rats. 30 male rats (250- 300gr) (n=6) were tested in 2 groups: control and morphine groups ( twice daily for 7 days) and divided in 4 sub groups: saline group which was received only saline and Mc group were received Mc extract (10, 20, 50mg/kg I.P) in day 7, 30 min before naloxane administration. In the end of training day all groups were received naloxane (5mg/kg I.P) 3h after last injection of morphine and then the frequencies of withdrawal behavior were assessed for 30min. Our results show that I.P administration of MC extract dose dependently attenuates most of morphine withdrawal syndrome. These result suggested that injection of MC extract in to the I.P are helpful for morphine withdrawal syndrome treatment.

 
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