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Paper Information

Title: 

EVALUATION OF ANTICONVULSANT ACTIVITY OF LACTUCA SATIVA SEEDS AND ASPERUGO PROCUMBENS LEAVES

Type: POSTER
Author(s): MOHAMMADI PEYMAN*,MOJAB F.,SHAFAGHI B.
 
 *SCHOOL OF PHARMACY, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Epilepsy is a chronic disorder which is accompanied by reparative and self-limiting convulsion. In Iranian traditional medicine, many herbal drugs have been used for treatment of epilepsy. Nowadays many cases of epilepsies are controlled by using the current official antiepileptic medications but these drugs have various side effects on the other hand. There are also drug resistant convulsions which are refractive to these drugs. Therefore herbal medicines have been considered as a source of new anticonvulsants. In this Study anticonvulsant activity of methanolic (80%) extract of leaves of Asperugo procumbens and seeds of Lactuca sativa were evaluated in male NMRI mice, using pentylentetrazole (PTZ) and maximal electroshock (MES) models.
The results showed that total methanolic extract of Asperugo procumbens have significant anticonvulsant activity at dose of 20-320mg/kg in MES model (ED50= 173.9mg/kg with 95% confidence interval of 56.204-1869.203mg/kg), but at doses up to 320 mg/kg has no effect in PTZ model. Total methanolic extract of Lactuca sativa has no any significant anticonvulsive activity in both PTZ and MES models.
Then, total methanolic extract of Asperugo procumbens leaves fractionate with 3 solvents including etherdepetrol, chloroform and ethylacetate and anticonvulsant activity of them was considered. Chloroform fraction showed anticonvulsant activity in MES model (ED50= 202.92 mg/kg with 95% confidence interval 66.034- 2723.197 mg/kg).

 
Keyword(s): ASPERUGO PROCUMBENS, LACTUCA SATIVA, ANTICONVULSANT, PTZ, MES
 
 
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