Paper Information

Title: 

THE EFFECT OF OLEA EUROPAEA FEEDING ON BLOOD GLUCOSE AND LIPID LEVEL IN DIABETIC RATS

Type: POSTER
Author(s): GHOUSIAN MOGHADAM M.H.*,ROGHANI MEHRDAD,MASOUMI Y.
 
 *DEPARTMENT OF BIOCHEMISTRY, SCHOOL OF MEDICINE, SHAHED UNIVERSITY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Use of medicinal plants for attenuation of hyperglycemia and restoration of lipids to normal level is clinically very important. In this study, the effect of oral administration of Olea europaea (OE) on serum glucose and lipids in diabetic rats was investigated.
Male Wistar rats were divided into 4 groups, i.e. control, OE-treated control, diabetic, and OE-treated diabetic groups. The treatment groups received oral administration of plant-mixed pelleted food. Serum glucose and lipids levels were determined before the study, and at 3rd and 6th weeks after the study. Serum glucose was significantly lower in OE-treated diabetic rats at 6th week as compared to untreated diabetic (p<0.01). In addition, serum total-cholesterol and triglyceride showed a significant reduction at 6th week in OE-treated diabetic rats as compared to untreated diabetics (p<0.01-0.005). There was also a significant improvement in HDL- and LDL-cholesterol levels in treated diabetic group as compared to untreated diabetic group (p<0.01-0.005).
Oral administration of OE has a significant hypoglycemic effect and in long term leads to appropriate changes in serum lipid profile in diabetic rats.

 
Keyword(s): OLEA EUROPAEA, DIABETES MELLITUS, GLUCOSE, LIPID
 
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