Paper Information

Title: 

RELATION OF BCG-SCAR DIAMETER AND ASTHMA IN CHILDREN

Type: PAPER
Author(s): ALE YASIN S.,ASADI SAMAN*,KATIBEH P.,AMIN REZA
 
 *ALLERGY & IMMUNOLOGY RESEARCH LAB, PEDIATRIC DEPARTMENT, MEDICAL UNIVERSITY OF SHIRAZ
 
Name of Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Type of Seminar:  CONGRESS
Sponsor:  IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES
Date:  2007Volume 6
 
 
Abstract: 

There are conflicting ideas about the inverse relationship between delayed type hypersensitivity reaction of BCG and atopic state. Stronger response to PPD test as an indicator of more potent TH1 response is supposed to influence TH2-modulated allergic reactions, but it is still doubtful whether scar of BCG vaccine can also be supposed as an indicator of TH1-immune response or not. In our previous study PPD test response was significantly smaller in asthmatic patients, now in this study the relationship between BCG scar and asthma is investigated.
Methods: 100 patients younger than 5 years old, vaccinated at birth, with variable severity of asthma were compared to the same number of age-adjusted healthy control group in a case-control study. Mean of vertical and longitudinal diameter was determined. At the same time, the severity of asthma in the case group was evaluated (according to classification of national institutes of health, national institutes of heart lung and blood), by asking mothers about the frequencies of night and day symptoms or intervals of attacks. The patients were divided to three groups: Mild, Moderate and Severe groups (Mild intermittent and mild persistent groups were classified as one).
Result: In 97 case group the mean size of BCG scar was 4.93mm±1.89mm, again in 97 control group the mean size was 4.94mm±1.46mm (P=0.949).
Conclusion: contrary to the result of our previous research which showed a significant reverse relation between PPD-skin test response and asthma, but no significant relation was found between BCG scar and asthma, which suggests that BCG-scar is not a good indicator of TH1 response and is probably related to other mechanism such as wound healing.

 
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