Paper Information

Title: 

EVALUATION OF SILYMARIN EFFECT ON CATALASE ACTIVITY IN RATS INTOXICATED WITH CADMIUM

Type: POSTER
Author(s): BABAEI ZARCH A.*,MOZAFARI HASAN,FALAH HOSSEINI H.,MAHDAVI SEYED MOJTABA
 
 *DEPT. OF PHARMACOLOGY, SCHOOL OF MEDICINE, YAZD UNIVERSITY OF MEDICAL SCIENCE,YAZD
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Because silymarin has been known as an antioxidant and widely used for treatment of liver disorders, The present study was designed to evaluate the antioxidant effect of silymarine on cadmium-induced hepatic dysfunction and catalase activity in rats.
Adult male Wistar rats were administered cadmium by injection of 0.3mg /kg bw/ every week for six weeks. In six group of rats different doses of silimarine were added to drinking water during cadmium administration and in another six group different doses of silimarine were administered during six week after cmpletation of cadmium intoxication.
Cadmium administration (0.3 mg/kg i.p) decreased serum catalase activities after six week of treatment in relation to control group (only received vehicle of cadmium) which was statistically significant (P<0.05). In groups of rats receiving different doses of silymarine (75ppm, 150ppm, 300ppm, 600ppm and 1200ppm), silymarine dose dependently increased serum catalase activity, which were statistically significant at doses of more than 150ppm (P<0.5). In groups of rats receiving different doses of silimarine after completation of cadmium intoxication, silimarine also dose dependently increased serum catalase activity. Indeed, silymarine significantly increased (p<0.05) antioxidant enzymatic activities in rat serum, compared to those given cadmium alone. Chamges observed in catalase activities are incosistance with those observed in serum AST, ALT and ALP activities in this study.
Oral administration of silymarine, alone or with cadmium significantly improved cadmium-induced liver dysfunction.

 
Keyword(s): SILYMARINE,CAMIUM TOXICITY,CATALSE, AST, ALT.ALP
 
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