Paper Information

Title: 

COMPARATIVE STUDY OF ORAL & IP ADMINISTRATION OF TRIBULUS TERRESTRIS EXTRACT EFFECTS ON SERUM BLOOD TOTAL PROTEIN AND PROTEIN FRACTIONS IN RAT

Type: POSTER
Author(s): ABSHENAS J.,HAMZEH G.,ABBASI RAEINI N.*
 
 *VETERINARY ADMINISTRATION ORGANIZATION OF KERMAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Tribulus Terrestris is a plant which grows all over the world. this herbal drug has been used in Indian and Chinas traditional medicine for many years. it's fruit is used for the treatment of renal infections, orbital infections, diabetes and leukorrhea. The aim of present study is to campaire the effect of administration method on serum blood total protein and protein fractions. In order to do this research we selected 40 male adult rats with the weight of 240-300gr. Then rats were divided into 4 groups accidentally. One of the treatments groups were administrated orally and the other group was administrated IP 10 mg/kg of herbal drug extract for 7, 14 and 28 days. At the end of the study blood samples were taken from heart under anesthesia and total protein and protein fractions were measured by the means of Pars Azmoon industry kits and auto analyzer auto lab apparatus and statistic studies were done. The results ofthis study show that IP administration for 14 days (8±0.2mg/dl) has the most effect increase in the total protein and protein fractions rate. But oraladministration for 14 days (6.67±0.19mg/dl) total protein and protein fractions rates decreased. The albumin rate increased in IP administration 14 days (3.6±0.17mg/dl) and deceased in 28 days (3.2±0.18mg/dl). the rate of total globulins increased in IP administration 14 and 28 days (4.4±0.2mg/dl) and decreased in oral administration 14 days (3/06±0.25mg/dl). Considering the effect of method of administration on this herbal drug extract effects more researches are needed in this case.

 
Keyword(s): TRIBULUS TERRESTRIS. IP, TOTAL PROTEIN, RAT
 
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