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Paper Information

Title: 

COMPARISON OF ANALGESIC EFFECTS OF AQUEOUS EXTRACT OF TRACHYSPERMUM AMMI WITH DICLOFENAC IN MALE RATS

Type: POSTER
Author(s): SARGAZI M.*,KOMEYLI GH.R.,MALEKI SH.A.D.,SOLOUKI S.
 
 *MEDICAL STUDENT RESEARCH COMMITTEE, ZAHEDAN UNIVERSITY OF MEDICAL SCIENCE
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Background: Although Diclofenac is one of the important analgesic drugs used, because of its many side effects, including damage to the liver, muscle, gastrointestinal tract, central nervous system and most important of all, it increases the risk of heart stroke, there is less willingness to use it. Using medicinal plants in ancient times for pain was common and it is still increasing. Analgesic effects of aqueous extracts Trachyspermum ammi and diclophenac were compared in this study.
Materials and Methods: In this experimental study 50 male wistar rats with the approximate weight of 200±20 gr were used. Aqueous extract Trachyspermum ammi (50, 125 and 250 mgr/kg) and volume of the solution Diclofenac (100 mgr/kg), 15 minutes before formalin testing as animals were injected into the peritoneum. Pain assessment criteria were testing the length of time keeping up, licking and biting the limbs in acute stages (first 5 minutes) and chronic (15 to 45 minutes) after injection of formalin (25 microlitres of solution 2.5 percent) in animal foot.
Results: The results showed that aqueous extract of Trachyspermum ammi significantly reduces the reply to pain stimuli (p<0.05). Analgesic effect Trachyspermum ammi plant dose of 250mg/kg in both phases of pain (acute and chronic) was clearer than other doses. The analgesic effect of this plant with the 250mg/kg dose showed significant difference to analgesic drug effects Diclofenac (100mg/kg) in both phases of pain (p<0.05).
Conclusion: Results indicate that the appropriate dose of Trachyspermum ammi aqueous extract reduce chronic pain and operates more effective than Diclofenac. To discover the mechanism of this analgesic plant more research is needed.

 
Keyword(s): ANALGESIC, AQUEOUS EXTRACT, TRACHYSPERMUM AMMI, DICLOFENAC,RAT
 
 
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