Paper Information

Title:  EVALUATION OF BENEFICIAL EFFECTS OF ZATARIA MULTIFLORA BOISS IN HALOTHANE-INDUCED HEPATOTOXICITY IN RAT
Type: POSTER
Author(s): SISTANI F.*,ABBASI RAEINI N.,ETEMADI L.,AZARI O.,SAKHAEI E.A.,SHARIFIFAR FARIBA
 
 *SCHOOL OF VETERINARY MEDICINE, SHAHID BAHONAR UNIVERSITY OF KERMAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Halothane is one of the most important anesthetics commonly used for anesthetizing of humans and animals. In some studies, hepatic injury was occasionally induced in animal models as a result of interaction of halothane exposure, induction of liver enzymes, and hypoxia, especially after multiple halothane exposures over short periods. Zataria multiflora is a valuable medicinal plant owned by the Labiatae family that anti-inflammatory effects against acute and chronic inflammations in mice and rats. In this study Thirty-two male rats (Wistar) were kept in the Center for Laboratory Animal Care at the Veterinary Medicine Faculty of Shahid Bahonar University of Kerman for 1 week before treatment. They divided to four different groups for 7 days as follows: control animals (Group C), which did not receive any treatment. Group Z which received Zataria multiflora extract during experiment period (7 days); Group H which exposed to an anesthetic gas mixture in the vaporizer using the semi-closed method for 2 hours on 6th day, and Group T, Zataria multifloratreated animals, which received 5 days pretreatment with Zataria multiflora and exposed to the anesthetic gas mixture for 2 hours on 6th day, and then Zataria multiflora was continued until 7th day. Serum levels of AST, ALT, ALP, LDH and TBIL were significantly increased (p<0.05) by halothane anesthesia (Group H) in compare with group C. The mentioned parameters except AST were significantly decreased (p<0.05) in group T in compare with group H. There was no significant difference in concentration of all of enzymes and T-BIL between groups C and Z (p>0.05). In conclusion, we have determined that halothane anesthesia affected some liver enzymes and some other biochemical parameters. Zataria multiflura may prevent the increase of some biochemical and hematological parameters after halothane anesthesia. Based upon our results Zataria multiflora extract may have a prophylactic effect in the prevention of halothane hepatotoxicity complications, It is recommended to prescribe Zataria multiflora extract as pretreatment for patient with hepatic disorders at least 5 days before anesthesia.

 
Keyword(s): HALOTHANE, ZATARIA MULTIFLORA, HEPATOTOXICITY, RAT
 
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