Paper Information

Title: 

IL-8 (−251 A/T) AND CXCR2 (+1208 C/T) GENE POLYMORPHISMS AND RISK OF MULTIPLE SCLEROSIS IN IRANIAN PATIENTS

Type: PAPER
Author(s): ALIPARASTI M.R.*,NIKSERESHT A.R.,KAMALI SARVESTANI E.
 
 *DEPARTMENT OF IMMUNOLOGY, MEDICAL SCHOOL, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN
 
Name of Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Type of Seminar:  CONGRESS
Sponsor:  IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES
Date:  2007Volume 6
 
 
Abstract: 

Introduction: IL-8 plays important roles in CNS development, modulation of neuronal survival and excitability. Among IL-8 receptors, only CXCR2 is known to be present in the brain. The ability of individuals in producing IL-8 is partially determined by IL-8 −251 A/T polymorphism. Therefore, the aim of the present study was to investigate the association between IL-8 −251 A/T and CXCR2 +1208 C/T gene polymorphisms and susceptibility to multiple sclerosis (MS).
Subjects and Methods: Two hundred and twenty-three MS patients and 319 healthy and ethnic matched controls were included in this study. IL-8 promoter (−251 A/T) and CXCR2 (+1208 C/T) gene polymorphisms were genotyped via allele specific PCR (AS-PCR) method.
Results & Discussion: A significant difference was found in IL-8−251 A/T polymorphism between MS patients and controls (p=0.04). This deference was a result of a higher incidence of the low producer allele of IL-8 (T allele) in MS patients compared to controls. The results became more significant when the patients and controls were classified (TT) and (AT + AA) genotypes (p=0.02).we suggest that in initial steps of infection, lower ability in recruitment of immune cells to CNS in IL-8 −251 T allele carriers may lead to slower eradication of viral infection which cause increased damage to CNS. However we hypothesized that individuals with IL-8 −251 TT genotype are more susceptible to MS development because they may not be able to repair neuronal damage as efficiently as IL-8 −251 A allele carriers.  However, no significant association existed between CXCR2 +1208 C/T polymorphism and MS susceptibility or different clinical parameters in patients.
Conclusion: In summary, carriers of IL-8 −251 T allele may have increased susceptibility to MS because of their differences in neuron survival or increased chances of viral persistence compared to carriers of A allele.

 
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