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Paper Information

Title: 

EFFECTS OF SAFFRON AND ITS ACTIVE CONSTITUENTS, CROCIN AND SAFRANAL, ON BLOOD GLUCOSE LEVELS IN ALLOXAN DIABETIC RATS

Type: POSTER
Author(s): KIANBAKHT S.*,HAJI AGHAEI SAEID
 
 *INSTITUTE OF MEDICINAL PLANTS, COMPLEX OF ACADEMIC CENTER FOR EDUCATIONAL AND CULTURAL RESEARCH (ACECR), KAVOSH BOULEVARD, SUPA BOULEVARD, 55TH KILOMETER OF TEHRAN-GAZVIN FREEWAY, POULEH KORDAN, KARAJ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Background and objective: Diabets mellitus is a prevalent metabolic disorder. Oral anti-diabetic agents and insulin used to lower blood glucose levels in diabetic patients can not always control blood glucose levels and prevent the complications of diabetes. Thus finding new and efficacious anti-diabetic agents is important. Saffron has been used in traditional medicine as a hypoglycemic agent in the treatment of diabetes. The objective of this study was to evaluate the effects of saffron and its active constituents, crocin and safranal, on fasting serum glucose, glycosylated hemoglobin, liver enzymes (SGOT and SGPT) and creatinin levels in alloxan diabetic rats.
Materials and methods: Male Wistar rats in groups of 10 were made diabetic by intraperitoneal injection of alloxan at a single dose of 125 mg/kg. After 2 weeks of alloxan injection the effects of daily intraperitoneal injection of saffron 80% methanolic extract, crocin and safranal for 1 month on fasting serum glucose, glycosylated hemoglobin, liver enzymes and creatinin levels of diabetic rats were assessed and compared with the control diabetic (normal saline) group.
Results: Saffron extract (80 mg/kg), crocin (50 mg/kg) and safranal (0.5 ml/kg) reduced fasting serum glucose and glycosylated hemoglobin levels as compared with the control group after 1 month of daily administration (P<0.01). Saffron, crocin and safranal did not have any significant effects on serum liver enzymes and creatinin levels as compared with the control group (P>0.05).
Discussion and conclusion: Saffron can decrease blood glucose in diabetic rats without hepatic and renal toxicity. Crocin and safranal are involved in this effect of saffron.

 
Keyword(s): SAFFRON, CROCIN, SAFRANAL, DIABETES MELLITUS, RATS
 
 
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