Paper Information

Title: 

THE EFFECT OF URTICA DIOICA HYDRO-ALCOHOLIC EXTRACT ON PITUITARY-GONAD AXIS AND HISTOLOGICAL CHANGES OF TESTIS IN ADULT RATS

Type: POSTER
Author(s): BEHTASH M.*,SHARIATI MEHRDAD,MOKHTARI MOKHTAR
 
 *ISLAMIC AZAD UNIVERSITY, KAZEROUN BRANCH, DEPARTMENT OF BIOLOGY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Urtica dioica is a dioecious, herbaceous, perennial plant consisting of compounds including: palmitic-acid, linoleic-acid, ferulic-acid, scopoletin, serotonin and sitosterol .In present research the effect of this plant on the level of gonadotropin and testosterone hormones were studied. In this experimental study, the experiments were performed on 40 male wistar rats weighting 190-200 g, which were divided into 5 groups of 8. The experimental groups received 25, 50 and 75 mg/kg of the Urtica dioica extract in-peritoneum for 28 days respectively. The observation group received only solvent (distilled water) and the control group was given nothing but water and food. Statistical analysis of the data was performed using ANOVA and t-test where appropriate.
The results achieved through hormonal analysis indicated that the 75 mg/kg of Urtica dioica hydro-alcohol extract decreases significantly the level of testosterone in blood serum at p<0.05, while no significant difference was seen at FSH and LH hormone level of blood serum. The histological investigations of testis showed that the concentration of sperm, the numbers of spermatogonia, primary spermatocyte , spermatid and leydig cell in group resaving maximum dose decreased significantlyin respect to control group.
It is possible that sitosterol present in Urtica dioica extract causes a decrease in testosterone level by decreasing cholesterol level. In addition this extract may cause weakens in testicular function as well as decrease in testosterone level and interference in spermatogenesis chain through the direct effects on testicular tissue.

 
Keyword(s): URTICA DIOICA, TESTOSTERONE, SPERMATOGENESIS, GONADOTROP
 
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