Paper Information

Title:  THE EFFECT OF ANTINOCICEPTIVE HYDRO-ALCOHOLIC EXTRACT OF LEAVE MENTHA PULEGIUM IN FORMALIN TEST IN ADULT MALE RAT
Type: POSTER
Author(s): MOKHTARI MOKHTAR*,SHARIATI MEHRDAD,KHODAPARAST L.
 
 *ISLAMIC AZAD UNIVERSITY, KAZEROUN BRANCH, DEPARTMENT OF BIOLOGY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Therefore research for finding new antinociceptive is necessary. In the present study the Effect of Antinociceptive Hydro-Alcohol Extract of Mentha pulegium Leave was evaluated in male Rat.
In this experiment 40 adult male wistar rats, was used each weighting about 220- 230g. Antinociceptive was evaluated by formalin test in five groups of eight including three experimental groups received 400, 800, 1600 (mg/kg) from hydro-alcohol extract leave of Mentha pulegium respectively; the sham group received only distilled water and formalin and the control without nothing care. The extracts were intraperiotoneally injected 15 minutes before the formalin test Minute 0-5 and 15-60 were designated respectively as the acute and chronic phase of pain. After recording behavioral responds were evaluated among experimental group and control group by statistical method for example Tukey and t-test. (P<0.05).
The mean and the standard error of measurement of pain score in experimental group, in the acute stage of formalin test with doses of 400, 800, 1600 (mg/kg) were 1.805±0.040, 1.706±0.034 and 1.605±0.26 respectively and in the chronic stage with dose of 1600 mg/kg was 1.469±0.09. That showed significantly different with control group (P<0.05).
According to the results of this research, the Hydro-Alcoholic extract of the leaves of menthe pulegium reduces the pain in the acute stage more than chronic stage. However, more research is needed to recognition be conducted on effective antinociceptive compounds of menthe pulegium.

 
Keyword(s): MENTHA PULEGIUM, PAIN, RAT
 
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