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Paper Information

Title: 

ANTIDEPRESSANT ACTIVITY OF AQUEOUS EXTRACT OF HYPERICUM SCABRUM L. AERIAL PART IN MALE MICE

Type: POSTER
Author(s): AHANGAR N.A.*,EBRAHIMZADEH M.A.,NABAVI S.M.,NABAVI S.F.,ESLAMI BAHMAN
 
 *DEPARTMENT OF TOXICOLOGY & PHARMACOLOGY, SCHOOL OF PHARMACY, MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, SARI, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Hypericum scabrum L. is a member of Hypericaceae family and previously antimicrobial, antihelmintic, antiulcerogenic and essential oil composition of this species were reported. Chemical investigations of some Hypericum species have shown flavanoids, xanthones, bisanthraquinones and other constituents present. Antidepressant activity of flavonoids (including quercetin) was reported previously. The aim of this study is the evaluation of antidepressant activity of Hypericum scabrum L. aerial part in mice.
Male Swiss mice (20-25 g) were used and antidepressant activity was measured by two experimental despair animal models, the tail suspension and the forcedswimming tests. Number of animal in each group was 6. The animals received different intraperitoneal injections of the extract (125, 250 and 500 mg kg-1). After 30 min, the average duration of immobility time was calculated in each group. Imipramine (15 mg kg-1) and normal saline were used as positive and negative control, respectively.
The 250 and 500 mg kg-1 doses of aqueous extracts significantly (p<0.01) reduced the duration of immobility period in both tests compared to normal saline. With 500 mg kg-1 dose, duration of immobility was less than imipramine (p<0.05), too.
These results represent potent antidepressant activity of Hypericum scabrum L. aqueous extract in mice. Some of these effects may be attributed to the high content of flavonoids in the sample. The central mechanisms of these effects need to be determined.

 
Keyword(s): HYPERICUM SCABRUM, ANTIDEPRESSANT ACTIVITY, FORCED- SWIMMING TEST, TAIL SUSPENSION TEST, FLAVONOID
 
 
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