Paper Information

Title: 

ANALGESIC EFFECTS OF SPARTIUM JUNCEUM FLOWERS EXTRACT IN RAT FORMALIN TEST

Type: POSTER
Author(s): HASANPOUR EZATI M.*,ABBASZADEH F.,MOUMENZADEH T.
 
 *DEPARTMENT OF BIOLOGY, SCHOOL OF BASIC SCIENCES, SHAHED UNIVERSITY, TEHRAN, GHOM, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Our objective was to study the analgesic activity of Spartium junceum L. flowers (Fabaceae) aqueous extract on inflammatory pain model in rats. Previously, the analgesic effect of its alcoholic and hexane extract has been reported on rat tail flick test and mechanical pain models, but these extracts are toxic and not suitable for clinical use. Samples of flowers were collected from wild plants, dried rapidly by microwave, powered and extracted. The extracts were evaporated by microwave to dryness and then the resulted powder suspended in normal saline. In this study, the analgesic activity of extract investigated by rat (Sprague- Dawley, 200- 250g) formalin test (n=7). Intraperitoneal injections of different doses of extracts (10, 100, 500 mg/kg) reduced the pain scores in both phases of formalin test in comparison with control (p<0.05). According to results Intraperitoneal injections of sodium salicylate (300 mg/kg) reduced pain in second phase of formalin test significantly (p<0.01). The preliminary phytochemical studied showed that the extract contains flavonoids & saponin. Our investigation show that Spartium junceum flowers aqueous extract possess significant and dose dependant analgesic effect only on second phase of formalin test. Thus extract have anti-inflammatory analgesic activity near to sodium salicylate effective dose.

 
Keyword(s): FORMALIN TEST, SPARTIUM JUNCEUM EXTRACT, RAT
 
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