Paper Information

Title: 

PROTECTIVE EFFECTS OF SALVIA VERTICILLATA DURING SERUM/GLUCOSE DEPREVIATION METHOD IN PC12 CELLS

Type: POSTER
Author(s): HOSSEINI ARMAN*,SADEGHNIA H.R.,KAMALINEZHAD MOHAMMAD,ASGHARI MOZHGAN,SHAFIEI SH.,GACHPAZ S.,NADERI NIMA,AFKHAMI AMIR,EBRAHIMI ROUJA
 
 *DEPARTMENT OF PHARMACOLOGY, FACULTY OF VETERINARY MEDICINE, FERDOWSI UNIVERSITY OF MASHHAD, MASHHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Salvia verticillata (purple rain or lilac sage), a Eurasian species used locally in folk medicine and as a garden ornamental, has been reported as an antioxidant and due to its polyphenols, volatile oils and diterpenoids contain. Herein, we have studied the protective effects of alcoholic/aqueous (70)/30) extract of Salvia verticillata on Rat Pheochromocytoma cells (PC12) during the Serum/Glucose Deprivation (SGD) model in a DMEM medium. Two way ANOVA followed by Tuckey-krammer as post hoc. test was performed as statistical analysis. Addition of the alcohol free Salvia verticillata extract increased viability of the cells in a concentration-dependent manner as revealed by an absorbance increase percentage in MTT assay from 18.78±3.95 in SGD group to 13.19±0.52, 17±0.63, 23.43±0.42, 28.42±2.89, 66.06±3.32 and 97.62±8.41 respectively (n=8). These findings if shown to be true during in vivo studies as well, can rise new hope in treatment of different oxidative stress mediated diseases.

 
Keyword(s): SALVIA VERTICILLATA, PURPLE RAIN, ANTIOXIDANT, SERUM/GLUCOSE DEPRIVATION
 
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