Paper Information

Title: 

EFFECT OF SAFRANAL ON EXTRACELLULAR HIPPOCAMPAL LEVELS OF GLUTAMATE AND ASPARTATE DURING KAINIC ACID TREATMENT IN ANESTHETIZED RATS

Type: POSTER
Author(s): SADEGHNIA H.R.*,HOSSEINZADEH HOSSEIN,RAHIMI ATENA
 
 *DEPARTMENT OF PHARMACOLOGY, DEPARTMENT OF MODERN SCIENCES AND TECHNOLOGIES, SCHOOL OF MEDICINE, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, I.R. IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Anti-seizure effects of safranal, a constituent of Crocus sativus L., have been evaluated in several experimental models. In this study, the effect of safranal pretreatment on concomitant changes in the extracellular hippocampal levels of excitatory amino acids (EAA, i.e. glutamate and aspartate) following systemic administration of kainic acid (KA) was investigated in anesthetized rats. Safranal (72.75 mg/kg or 291 mg/kg, i.p.) was injected 40 min before KA (15 mg/kg, i.p.). A group of rats also received diazepam (DZP, 15 mg/kg, i.p.) 20 min prior to KA administration. The basal hippocampal concentrations of glutamate and aspartate were estimated to be 0.51±0.02 μM and 0.28±0.01 μM, respectively. Basal EAA levels were not affected by pretreatment with safranal. Following KA injection, there was a significant increase (p<0.001) in the extracellular glutamate and aspartate levels (about 5-fold and 3-fold, respectively) at 80 min after injection. However, the kainite-evoked release of EAA was significantly reduced by DZP (p<0.001) and safranal (291 mg/kg, i.p.; p<0.001). The results of this study show that acute systemic injection of safranal reduces the extracellular concentrations of glutamate and aspartate in the rat hippocampus following KA administration.

 
Keyword(s): KAINIC ACID, GLUTAMIC ACID, ASPARTIC ACID, HIPPOCAMPUS, SAFRANAL, CROCUS SATIVUS
 
Yearly Visit 19   tarjomyar
 
Latest on Blog
Enter SID Blog