Paper Information

Title: 

FREQUENCY OF ATOPIC ASTHMA AMONG SULFUR MUSTARD INDUCED ASTHMA IN IRANIAN VETERANS: CASE-CONTROL STUDY

Type: PAPER
Author(s): AGIN KH.*
 
 *LOQMAN HAKIM TEACHING HOSPITAL, SHAHEED BEHESHTI UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: BIENNIAL CONGRESS ON IMMUNOLOGY, ASTHMA AND ALLERGY
Type of Seminar:  CONGRESS
Sponsor:  IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES
Date:  2007Volume 6
 
 
Abstract: 

Introduction: Sulfur mustard (SM), used as a potential chemical warfare agent, is able to develop asthma disease. A link between allergy and asthma has long been recognized. The atopy is common among adults with asthma. Phenotypic patterns of asthma are expressive of diversity in clinical features between atopic and non-atopic types, such as onset of disease, response to therapy, and type of bronchial hyper-responsiveness. The purpose of the study was to determine prevalence of atopic asthma between SM induced asthma in Iranian veterans, to compare with non-exposed control asthma, and to assess the status atopic markers between groups of the study. The study has not been performed in Iran and other countries yet.
Materials and Methods: the protocol comprised a randomized sample of SM induced asthma subjects, male, aged 32 to 67 years , were investigated in case-control study by using a questionnaire, skin-prick test (SPT) for 10 common aeroallergen extracts panel and measurement of total serum IgE antibody levels by ELIZA method. During two stages, the whole 63 subjects as a case were compared with 65 non-exposed control asthma participants.
Results: The prevalence of atopic asthma was found 60% and 18% in case and control groups, respectively. A highly significant improvement was noted between SM induced asthma (case) with non-exposed asthma (control) groups according to Pearson Chi-Square test (X<0.001). Age distribution was found among middle-age-adults. Mean total IgE levels and eosinophilia counts were significantly higher among case group and allergic exposed subgroups. Frequencies of SPT to various aeroallergens were notable. Frequencies of Rhinitis 58.7%, and urticaria 27% were significantly higher in allergic exposed subgroup.
Conclusion: The study demonstrated the high prevalence of allergic asthma and atopy between SM induced asthma compared to control subjects.

 
Keyword(s): ASTHMA, RESPIRATORY ALLERGY, ALLERGY, SULFUR MUSTARD GAS, IRANIAN, ADULTS
 
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