Paper Information

Title: 

EFFECT OF CENTRAL HISTAMINERGIC AND DOPAMINERGIC RECEPTOR AGONISTS ON WATER INTAKE IN ADULT MALE RATS

Type: POSTER
Author(s): SHARIF KHODAEI Z.*,ORYAN SHAHRBANOU,NAGHDI N.
 
 *DEPARTMENT OF BIOLOGY, SCIENCE FACULTY, TARBIAT MOALLEM UNIVERSITY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Thirst and salt appetite are important behaviors which help mammals to regulate plasma osmolarity, blood volume and blood pressure. Thirst which provides the motivation to drink is an important component of the coordinated sequence of physiological responses that maintain the volume and composition of body fluids. Special structures located in the strategic peripheral sites and the central nervous system like periventricular organs detected changes in these parameters continuously and accurately. The present study investigated the critical roles of histaminergic and dopaminergic receptor agonists on water intake in adult male rats. Intracerebroventricular (i.c.v) injections through cannulea in a lateral ventricle were carried out in all experiments after 24h deprivation of water. After deprivation the volume of consumed water was measured for 1h.
Central administration of Histamine, a histaminergic receptor agonist (80μg/rat) and Bromocriptine, a dopaminergic receptor agonist (10μg/rat) increased water intake in rats.
It is concluded that both histaminergic and dopaminergic receptor agonists could increase water intake through circumventricular organs. They have interactions with histaminergic and dopaminergic neurons which subsequently stimulate magnocellular argenin vasopressin (AVP) neurons. These events resulted in increase of AVP secretion and consequently water intake.

 
Keyword(s): WATER INTAKE, DRINKING, DOPAMINERGIC RECEPTORS, HISTAMINERGIC RECEPTORS.
 
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