Paper Information

Title: 

EFFECT OF CHRONIC MORPHINE ADMINISTRATION ON CA2+/CALMODULIN-DEPENDENT PROTEIN

Type: POSTER
Author(s): HAMIDI NAVID*,SEMNANIAN S.,JAVAN MOHAMMAD,FATH ELAHI Y.
 
 *TARBIAT MODARES UNIVERSITY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Opioids are some of the most efficacious analgesics used in clinical treatment. Chronic administration of opioids however causes the development of drug tolerance and dependency. CaMKIIa is one of the most important proteins that create morphine dependency. CaMKIIa is essential in learning and memory processes. Learning and memory are important in the development of dependency. Studies have shown that locus coeruleus nucleus is important in causing tolerance and dependency. In this research, we examined withdrawal signs in morphine dependent rats. Then we have cannulated LC and injected KN-93 (specific inhibitor of CaMKIIa activity) in this nucleus. We found that inhibition of CaMKIIa significantly attenuated the withdrawal signs precipitated by opiate antagonist naloxone. In contrast, KN-92, (the inactive structural analog of KN-93) failed to attenuate morphine dependency. These findings suggest that CaMKIIa is involved in the development of morphine dependency, and inhibition of this kinase may have some therapeutic benefit in the treatment of opiate dependency.

 
Keyword(s): CAMKII, KN-93, KN-92, DEPENDENCY
 
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