Paper Information

Title: 

EVALUATION OF THE EFFECT OF ELECTROCONVULSIVE SHOCK ON THE CENTRAL NGF PROTEIN AND THE ROEL OF CANNABINERGIC SYSTEM IN THIS REGARD

Type: PAPER
Author(s): HASANZADEH P.*,HASANZADEH ANA
 
 *DEPT. PHARMACOLOGY, FACULTY OF MEDICINE, AJA UNIVERSITY OF MEDICAL SCIENCES, TEHRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Enhancement of the neurotrophin levels in the brain has been considered as one of the mechanisms by which electroconvulsive shock (ECS) exerts its antidepressive effect. Considering the role of endocannabinoid system in the pathophysiology and treatment of depression, the present study was designed to investigate the effect of ECS on NGF protein level in different brain regions of rat and the role of the cannabinergic system in this regard.
Male Sprague-Dawley rats received acute and chronic ECS treatment. 24h after the last shock, rats were decapitated and NGF quantification was performed in the hippocampus, frontal cortex, amygdala and olfactory bulb using sandwich ELISA kit. In the case of NGF alteration, pretreatment with different doses of rimonabant (CB1 antagonist) was performed.
Acute ECS significantly increased NGF protein level in the hippocampus. Ten days of ECS treatment led to a remarkable augmentation of NGF level in the hippocampus, frontal cortex, amygdala, and olfactory bulb. Pretreatment with rimonabant (10mg/kg/i.p.) prevented enhancement of NGF protein induced by ECS.
These findings suggest that ECS under the influence of the cannabinergic system enhances NGF protein level in different brain regions. This may explain the efficacy of ECS in antidepressant-resistant depression.

 
Keyword(s): ELECTROCONVULSIVE SHOCK, NERVE GROWTH FACTOR, CANNABINERGIC SYSTEM, BRAIN, RAT
 
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