Paper Information

Title: 

NTICONVULSANT EFFECTS OF GUAIFENESIN AGAINST PTZ-INDUCED SEIZURE IN MICE

Type: POSTER
Author(s): KESHAVARZ MOJTABA,SHOURAKI A.R.,EMAM GHOREYSHI MASOUMEH
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Introduction: Guaifenesin is an expectorant used commonly as an OTC medication. It is also used as a muscle relaxant in anesthetic protocols in veterinary medicine. There have been some reports that guaifensin has beneficial effect in fibromyalgia due to its possible NMDA antagonist activity. Considering that drugs with similar structure to guaifensin (i.e. flebamate) and those with NMDA antagonist activity or muscle relaxant properties have been clinically used as an anticonvulsant; the aim of this study was to determine whether guaifensine has an anticonvulsant effect in an animal model of seizure.
Materials and methods: Anticonvulsant effect of guaifensin was assessed by pentylenetetrazole (PTZ)-induced convulsion. Male albino mice were received guaifensine (100, 200, 300 or 400 mg/kg; n=8-10), 0.25% tween (vehicle) or Diazepam (3mg/kg, n=8; reference drug) intraperitonealy 30 minutes before the injection of PTZ (95mg/kg). The latency time before the onset of myoclonic, clonic and tonic-clonic convulsions, the percentage of animals shown convulsion and the percentage of mortality were recorded. In addition, the effect of guaifensin on neuromuscular coordination was assessed using rotarod.
Results: Guaifensin at doses higher than 200 mg/kg significantly increased the latency of myoclonic, clonic and tonic-clonic convulsions in a dose-dependent manner. ED50 for protection against PTZ-induced clonic, tonic-clonic seizures and death were 744.88, 256 and 328 mg/kg, respectively. Guaifensin at doses higher than 100 mg/kg significantly reduced neuromuscular coordination compared to vehicle-treated group.
Conclusion: These results suggest that guaifensin have muscle relaxant and anticonvulsant effects and may have a potential use in convulsion.

 
Keyword(s): GUAIFENESIN, CONVULSION, PENTYLENETETRAZOLE
 
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