Paper Information

Title: 

EVALUATION OF ANTIMICROBIAL EFFECTS OF NOVEL QUINOLINE 4-CARBOXYLIC ACIDS

Type: POSTER
Author(s): ADIBI MOUNA*,MEHREGAN HADI,ZARGHI A.
 
 *DEPARTMENT OF PHARMACEUTICS, SCHOOL OF PHARMACY, SHAHID BEHESHTI UNIVERSITY (M.C.), TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Quinoline derivatives possess antifungal, antibacterial, antimalaria, anti- HIV, antitumor and herbicidal activities. Antimicrobial activity of novel 4- carboxylic acid quinoline derivatives was thus investigated in this study Overall, these compounds showed a significant antibacterial activity against GPBs such as methicillin-resistant Staphylococcus aureus (MRSA). However, the largest inhibition zone diameters were observed for Bacillus subtilis with 26-38 mm. Zone diameters obtained for C. albicans with about 21 mm was also remarkable. One of these compounds, i.e. 2-(4- (Methylsulfonyl) phenyl) benzo [h] quinoline-4-carboxylic acid could produce the largest inhibition zone with regard to aforementioned microorganisms. Furthermore, these compounds showed to have a weak inhibitory effect (zone diameter of 12-18 mm) on A. niger but almost no activity against GNBs, in particular Pseudomonas aeruginosa.
The diameters of zone inhibition produced by these quinoline compounds were usually larger than those of tobramycin against GPBs and amphotricin B against C. albicans, indicating their significant activity against these microorganisms. Considering the significant growth inhibitory effect on MRSA of test compounds, determination of structure-antimicrobial activity relationship, if any, in order to find related compounds with higher activity is recommended.

 
Keyword(s): QUINOLINE 4-CARBOXYLIC ACID, ANTIMICROBIAL EFFECT, METHYCILLIN, RESISTANT STAPHYLOCOCCUS AUREUS
 
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