Paper Information

Title: 

THE MODULATORY EFFECT OF LITHIUM ON DOXORUBICIN-INDUCED CARDIOTOXICITY IN RAT

Type: POSTER
Author(s): RAHIMI BALAEI M.*,DEHPOUR A.R.,EJTEMAEIMEHR SH.
 
 *DEPARTMENT OF PHARMACOLOGY, SCHOOL OF MEDICINE, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Doxorubicin (DOX) is an effective anti-neoplastic agent. However, application of this efficacious anti-cancer drug has been limited due to its cardiotoxic side effects. Lithium is widely used for treatment of neuropsychiatric symptoms in bipolar disorders but its mechanisms of action are not fully understood yet. Lines of evidence indicate the protective effects of lithium against ischemic injury in heart and another study which showed lithium chloride (a non selective GSK-3b inhibitor) blocked DOX-induced cardiomyocyte apoptosis in primary cardiomyocyte isolated from newborn rat heart ventricles. The purpose of this study was to investigate lithium heart protection against cardiotoxicity induced by DOX in rat model (in vivo study). Male Sprague-Dawley rats were treated with 300mg/Kg P.O. lithium in their water supply and/or DOX (1.25 mg/Kg I.P.), four times per week for four weeks. General condition, mortality rate and body weight were measured during the experiment. At the end of the experiment, ECG parameters and papillary muscle contractility force were assessed. Serum samples were collected for measurement of lithium concentration as well as cardiac troponin T level (a biomarker of cardiac injury). In addition, cardiac weight was measured and the cardiac tissues were evaluated both macroscopically and microscopically. We found that lithium can diminish mortality rate, general toxicity (edema, alopecia and cachexia), improve Sa-T segment and QT interval prolongation and heart contractility force. Application of lithium could inhibit the increase of cardiac troponin T and formation of myocardial lesions. All of these findings underscore the protective effect of lithium against DOX-induced cardiotoxicity in rat. On aggregate, the outcomes of the present study suggest that lithium might be considered as a new indication for prevention of DOX-induced cardiotoxicity.

 
Keyword(s): DOXORUBICIN, LITHIUM, CARDIOTOXICITY, RATS
 
Yearly Visit 21   tarjomyar
 
Latest on Blog
Enter SID Blog