Paper Information

Title: 

FATAL METHANOL POISONING: LIVER HISTOPATHOLOGY & TOXICOLOGIC FINDING

Type: POSTER
Author(s): PANAHIANPOUR M.H.,AKHGARI M.*,BAZMI E.,MAHDAVI S.A.H.
 
 *FORENSIC TOXICOLOGY DEPARTMENT, SCIENTIFIC AND EDUCATIONAL RESEARCH CENTER OF LEGAL MEDICINE ORGANIZATION (LMO), TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Background and Aims: Accidental or intentional methanol consumption has become a considerable alcoholic beverage poisoning in our country in which most cases are lethal. Ingested methanol is converted to highly toxic metabolites, formaldehyde and formic acid, by liver and this organ consequently show the most distinctive features of methanol poisoning. Therefore, it is our concern whether or not histopathology examination of liver tissue can provide valuable clues about the severity of methanol toxicity.
Methods: In a descriptive, cross-sectional study, 44 cases of lethal methanol poisoning were identified in a year, based on the predetermined level of methanol in blood and vitreous humor, and then the histological changes of the liver were reviewed and recorded for each case.
Results: Blood and vitreous humor methanol concentrations were 149.5±143.38 and 154.62±144.33 (mean±SD) respectively. The majority of cases were men (86.36%). Mean age of the cases was 37.36±14.95 years (mean±SD).
The most striking features of liver damage in light microscopy were:
Micro-vesicular steatosis (72.7%)
Macro-vesicular steatosis (34.1%)
Focal hepatocyte necrosis/ drop out necrosis (13.64%)
Mild intra-hepatocyte bile stasis (13.64%)
Vacuolar degeneration (13.64%)
Hydropic degeneration (9.1%)
Conclusions: To conclude, while the histopathologic findings of methanol poisoning in liver are not characteristic, in many cases varying degrees of steatosis will be expected. However, it seems unlikely that to find a rational relationship between the blood level of methanol and histologic changes of liver in light microscopy.

 
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