Paper Information

Title: 

THE EFFECTS OF TRIFLURALIN ON LIVER FUNCTION TESTS (LFT) IN ADULT MALE RATS

Type: POSTER
Author(s): SHARIATI MEHRDAD*,GHAVAMI MEHRNOUSH
 
 *ISLAMIC AZAD UNIVERSITY, KAZEROUN BRANCH, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

The purpose of this study was to investigate the Trifluralin pesticide with the power of controlling acetylcholinestrase in the nerve terminals.Because of its penetrating possibility into the body, the effects of the pesticide on the liver enzymes, LFT, have been explored. 40 adult rats (2.5-3 months) with the approximate weight of 190± 10gr were divided into five grops- control, sham, and 3 expremental (1, 2, and 3) -each with eight memders. The sham group received the pesticide (Organophosphate Diaznion) orally with a 50, 100, and 150 mg/kg dose once a day for 21 days. At the end of the period, after weighing the Rats, in order to measure the serum consentration of the enzymes and the other blood interfering factors, blood test was done. The livers were histologically investigated for the outside tissue alternations.
The measurement showed that Diazinon cause, a significant increase in ALP in all the experimental groups and ALP and AST in the experimental group 2 and 3 .The amount of albumin in the experimental group 3 and the total protein in all the experimental groups have decreased significantly . The tissue destruction was seen in the experimental groups 2 and 3. In spite of the all above-mentioned changes and the amount of bilirubin were not significant (p<0.05). It can be concluded that Diazinon, with the activation of the silent proteases, called caspase causing disorder in the phosphorilasion oxidative, decreasing in the gap junction, and increasing in the ACTH causes hepatitis destruction.

 
Keyword(s): TRIFLURALIN, LIVER FUNCTION TEST, HEPATOCYTE, RAT
 
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