Paper Information

Title: 

ACUTE TOXICITY EFFECT OF PARAOXON ON KIDNEY LIPID PEROXIDATION AND ANTIOXIDANT SYSTEM

Type: POSTER
Author(s): ABBASNEJAD MARYAM*,JAFARI MAHVASH,HAJI HOSSEINI REZA,ASGARI ALI REZA,HAJI GHOLAMALI M.,SALEHI MARYAM,SALIMIAN M.
 
 *DEPARTMENT OF BIOCHEMISTRY, APPLIED NEUROSCIENCES RESEARCH CENTER, FACULTY OF MEDICINE, MILITARY MEDICINE INSTITUTE, BAQIYATALLAH (A.S) UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Diazinon is one of the most widely used organophosphates in agriculture.
Toxic effects of diazinon are due to the inhibition of acetylcolinesterase, an enzyme needed for proper nervous system function. Investigates show that different classes of Ops may induce the production of free radicals and initiate lipid peroxidation leading to cell death, if the antioxidant system is impaired. The purpose of this study was to evaluate the effects of on diazinon oxidantantioxidant system in the kidney of rat.
In this study, Wistar rats (150-250 g body wt.) were randomly divided into five groups including: control, sham (corn oil) and three of groups of diazinon receiving different doses (30, 50 and 100 mg/kg) by intraperitoneal injection only once. 7 rats in each group were killed after 24 hours of exposure. The kidney of each groups were removed and the enzyme activities of superoxide dismutase (SOD) and catalase (CAT) as well as glutathione (GSH) and malondialdehyde (MDA) levels were determined by biochemical methods.
The results show that at concentrations higher than 30 mg/kg diazinon, the enhanced activities of CAT and SOD no change in MDA level was observed. The GSH level was significantly decreased. The data suggest that diazinon induces the production of free radicals and oxidative stress. The enhanced activity of antioxidant enzymes and depleted GSH content is indicative of oxidative tissue injury.

 
Keyword(s): DIAZINON, KIDNEY, ANTIOXIDANT SYSTEM, LIPID PEROXIDATION, RAT
 
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