Paper Information

Title: 

COMPARISON EFFECT OF VANADIUM AND DEFEROXAMINE ON ACETAMINOPHEN TOXICITY IN RAT

Type: POSTER
Author(s): MASOUDI A.M.*,MEHRZADI SAEID,NAJAFZADEH HOSSEIN
 
 *FACULTY OF VETERINARY MEDICINE, SHAHID CHAMRAN UNIVERSITY, AHVAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Acetaminophen can change to toxic metabolites at high dose, if these metabolites are at high amount, the body unable to neutralizing them, and several tissues including liver will damage. In present study, vanadium was compared with deferoxamine of hepatoxicity and also kidney function following acetaminophen administration in rats. The study was done in 5 groups (5 rats at each group): group 1 to 5 received normal saline, acetaminophen (apap), apap+deferoxamine, apap+vanadium and vanadium. The serum levels of alt, ast, bun, creatinine, sodium and potassium was determined and compared between groups. Apap significantly increased alt level and vanadium returns to normal level. The vanadium prevented increasing of ast by apap, while deferoxamine did not. The changes of factors, which related to kidney function, i.e. bun, creatinine, sodium and potassium wan not considerable. thus, with methodology of present study, the vanadium had better effect than deferoxamine on prevention of hepatoxicity induced by apap.

 
Keyword(s): ACETAMINOPHEN, VANADIUM, DEFEROXAMINE, HEPATOTOXICITY, RAT
 
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