Paper Information

Title: 

ORAL MORPHINE CONSUMPTION DELAYED LATERAL VENTRICLES AND CHROID PLEXUS IN WISTAR RAT EMBRYOS

Type: POSTER
Author(s): ESFANDIARI BEHNAZ*,KAZEMI MASOUMEH,AZARNIA MAHNAZ,SAHRAEI HEDAYAT,BAHADORAN H.
 
 *APPLIED NEUROSCIENCE RESEARCH CENTER, BAQIYATALLAH (A.S.) UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Previous studies have shown that morphine consumption during pregnancy may delay embryo development or cause abnormal nervous system function. The present study focused on the effects of maternal morphine consumption on choroids plexus development in Wistar rats. Wistar rats (170-200g) were used throughout. The experimental groups after pregnancy received 0.05 mg/ml of morphine by tap water while, the control group received water. On 17th day of pregnancy, the pregnant animals were anesthetized by chloroform and the embryos were removed surgically. The embryos were fixed in formalin 10% for 4 weeks. Then, tissue processing, sectioning and staining hematoxylin and eosin (H&E), were applied for the embryos. Severe reductions of the third as well as lateral ventricles were observed in the experimental group. In addition, an increase in the choroids plexus area in the experimental group regarding to controls was identified. The study showed that oral morphine consumption has caused to a decrease in the third and lateral ventricles and an increase in choroids plexus area. This defect may cause behavioral changes observed in the F1 generation from addicted pregnant animals.

 
Keyword(s): DEVELOPMENT, LATERAL VENTRICLES, CHOROIDS PLEXUS, MORPHINE, WISTAR RATS
 
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