Paper Information

Title: 

THE NEUROPROTECTIVE EFFECT OF WIN 55,212-2 AND NMDA INTERACTION IN NEUROTOXICITY INDUCED BY PARAOXON IN PC12 CELLS

Type: POSTER
Author(s): HASHEMI MANSOUREH*,BAHRAMI FARIDEH
 
 *PHYSIOLOGY & PHYSIC DEPT, BAQIATALAH UNIVERSITY OF MEDICAL SCIENCE, FACULTY OF MEDICINE, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Cannabinoids are a structurally diverse group of mostly lipophilic molecules that bind to cannabinoid receptor. In fact, endocannabinoids are a class of signaling lipids that are synthesized from lipid precursors in plasma membranes via calcium ions or G- protein- dependent processes and exhibit cannabinoid-like actions by binding to cannabinoid receptors. Following exposure PC12 cells to Paraoxon (200 μM), a marked reduction in cell survival was observed (P<0.001). Treatment of the cells with WIN 55,212-2 (0.1 μM) NMDA (100μM) prior to Paraoxon exposure significantly elevated cell survival (P<0.0001). Also, the cannabinoid antagonist (AM 251) did not inhibit the neuroprotection induced by WIN 55,212-2 (P<0.05). But, NMDA receptor antagonist (MK801) did inhibite neuroprotection induced by NMDA (P<0.001). These results indicate that WIN 55,212-2 and NMDA protect PC12 cells on paraoxon induced toxicity.In addition, the neuroprotective effect of WIN 55,212-2 and NMDA was cannabinoid receptor-independent and NMDA receptor dependent.

 
Keyword(s): WIN 55, 212-2, PARAOXON, NMDA, VIABILITYCB1
 
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