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Paper Information

Title: 

THE COMPARISON OF GLUTATHIONE REDUCTASE AND MYLEOPEROXIDASE ACTIVITY IN MINE ZINC AND LEAD EXPOSED WORKERS WITH CONTROL GROUPS

Type: POSTER
Author(s): TABATABAEI S.M.*,ORYAN SHAHRBANOU,MALEKIRAD A.A.,ABDOLLAHI M.
 
 *TABRIZ ISLAMIC AZAD UNIVERSITY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

lead causes oxidative stress by inducing the generation of reactive oxygen species, and reducing the antioxidant defense system .Oxidative stress which can create more than one hundred kind of diseases.Therefore the aim of this study is to determine and compare the glutathione reductase and myleoperoxidase activities in mine zinc and lead exposed workers with control groups.
This study is a case control analytical that 67 individuals who worked in in mine zinc and lead exposed as case group with 67 individuals as control group who was the same in terms of age and sex from the review point glutathione reductase and myleoperoxidase activity enzymes is comparsined.Activity of enzymes was evaluated by cayman kit.The results were analyzed with the use descriptive analysis (such as mean, deviation standard) and analytic analysis (such as t-test).
Mean and diversion of glutathione reductase and myleoperoxidase activity worker´s were in this manner: 99.89 ± 26.72nmol/min/ml, 12.05±6.07U/ml and in control group were in this manner: 87.96±40.32, 10.75±10.9.That the activity of glutathione reductase in case group significant increase in comparison to control group (p=0.004). That the activity of myleoperoxidase in the case group significant increase in comparison to control group (p=0.002). The results of this research show that in mine zinc and lead exposed workers glutathione reductase and myleoperoxidase activity significant increased.

 
Keyword(s): GLUTATHIONE REDUCTASE, MYLEOPEROXIDASE, REACTIVE OXYGEN SPECIES, ANTIOXIDANT DEFENSE SYSTEM, OXIDATIVE STRESS
 
 
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