Paper Information

Title: 

THE ROLE OF INTRA-LOCUS COERULEUS INJECTION OF 17β-ESTRADIOL IN INFLAMATORY PAIN MODULATION IN MALE RAT

Type: POSTER
Author(s): KHAKPAY R.*,SEMNANIAN S.,JAVAN MOHAMMAD,JANAHMADI MAHYAR
 
 *DEPARTMENT OF PHYSIOLOGY, TARBIAT MODARRES UNIVERSITY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Estradiol is a neuroactive steroid that is produced in several brain regions such as Locus Coeruleus (LC) and modulates nociception not only by binding to its receptors but also by allosteric interaction with other membrane-bound receptors like glutamate and GABAA receptors. LC is involved in noradrenergic descending pain modulation. Formalin test was used for assessing the pain modulatory effect of 17β-estradiol. Formalin-induced responses, licking and flexing duration and paw jerking frequency were recorded for 60 min after injection of 50 μl of 2% formalin. The current study showed that intra-locus coeruleus injection of 17b-estradiol attenuated the chronic phase of the formalin responses (P>0.05). The pure estrogen receptor antagonist, ICI 182,780, failed to antagonize the antinociceptive effect of 17b- estradiol. These results suggest that the analgesic effect of 17b-estradiol in inflammatory responses is not mediated through genomic estrogen receptormediated mechanisms.

 
Keyword(s): 17-β-ESTRADIOL, ICI 182, 780, LOCUS COERULEUS NUCLEUS, PAIN MODULATION, RAT
 
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