Paper Information

Title: 

INTHERATHECAL ADMINISTRATION OF DIGOXIN ACTS AS A LOCAL ANEASTHETIC AGENT

Type: POSTER
Author(s): SHARIFI G.*,SABET KASAEI M.,ERTEFAEI K.,SABERI M.,ALI ASGARI A.,HASHEMIAN M.R.,MASOUDNIA F.
 
 *
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Introduction: Digoxin inhibits Na/K ATPase (sodium pump) and relative reduction of calcium expulsion from the cell by the sodiumcalcium exchenger caused by the increase in intra cellural sodium. This function of digoxin stabilizes the cell membrane. On the other hand lidicaine a local anesthetic acts topically by blocking sodium channel and presynaptic calcium channel. In this study we cimpaired the analgesia effect of digoxin and lidocain via intherathecal administration.
Methods: Male SD rats weighing 250-300 gr were randomly divided into 7 groups (n=6). Intrathecal cathater (PE 10) was implanted 7 days before administration of drugs. The spinal anesthetic effect of drugs at 3 different doses digoxin (2.5 microg-1.25 microg and 0.625 microg) lidocaine (10 microg-50microg and 100 microg) and N/S 0.9% 10 microl were compered. The tail-flick test was used to evaluate the sensory impairment. Motor function was assested by voluntary wheel running distance.
Results: The percent of the maximal possible effect (% MPE) was greatest after 10 minutes in each group digoxin at the dose of 2.5 microg produced a %MPE of 103.0±2.1 whereas lidocaine at the dose of 100 microg produced a %MPE of 16.4±5.2. No statistically significant difference was found in the mean of maximum or total distance moved between any of the groups.
Conclusions: intrathecal digoxin had a more potent and longer duration of spinal anesthetic effect than did lidocaine. The sensory impairment was reversible and no motor dysfunction was observed at the given doses.

 
Keyword(s): INTHERATHECAL, DIGOXIN, RAT
 
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