Paper Information

Title:  EFFECTS OF SOCIAL STRESS ON THE TESTOSTERONE CONCENTRATION AND PAIN PERCEPTION IN MALE RATS
Type: POSTER
Author(s): DAKHESH S.,ZAREEIAN P.*
 
 *DEPTARTMENT OF PHYSIOLOGY, AJA UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Previous findings have indicated that stress may have an important role in the modulation of acute and chronic pain and the level of plasma testosterone. The present work investigated the effect of social stress on serum testosterone and pain perception in rat. In this experiment used 80 Sprague-Dawley rats were used. Invader rats were used for production of social stress. The animals were divided into 4 groups, as below: C1 group that existed out of invader rat’s room. C2 group that, existed in invader rat’s room for 5 days consecutively; the subject rats (S1, S2) that contacted with invader rats for 30 minutes and 4 hours per day for 5 days; on sixth day, after Tail Flick test, bloods from heart were collected. The Radio immunoassay method was used for assessment of serum testosterone. Testosterone level in S1 (1.8±1.4 ng/ml) and S2 (1.2±0.56 ng/ml) groups diminished significantly in comparison with C1 (8.6±5.2 ng/ml, p=0.001, p=0.00) and C2 (5.7±4.7 ng/ml, p=0.02, p=0.01) groups. Tail-Flick latency did not decrease significantly in S1 (5.3±1.2s) group in comparison with C1 (5.8±1.6s, p=0.5) and C2 (4.2±0.6s, p=0.06) groups. Whereas Tail-Flick latency decreased significantly in S2 (4.18±1.4s) group in comparison with C1 (5.8±1.6s, p=0.03) group. The present data showed that severe social stress induces hyperalgesia and mild social stress induces analgesia in male rats. Testosterone concentration decreased under severe and mild social stress.

 
Keyword(s): SOCIAL STRESS, TESTOSTERONE, PAIN, RAT
 
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