Paper Information

Title: 

PAPAVER RHOEAS (L.) WATER-ALCOHOLIC EXTRACT REDUCES FORCED SWIMMING TEST (FTS) IN MALE AND FEMALE MOUSE: A COMPARISON STUDY WITH FLOUXETINE

Type: POSTER
Author(s): MEMAR JAFARI M.R.*,SAHRAEI HEDAYAT,RAHIMZADEH BEHZADI H.,MOUSAVI KHOSRAVI S.A.,JAVID F.,PIRPIRAN M.,GOLMANESH L.
 
 *DEPARTMENT OF PHYSIOLOGY AND BIOPHYSICS, SCHOOL OF MEDICINE AND APPLIED NEUROSCIENCE RESEARCH CENTER, BAQYIATALLAH UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Depression is among most frequent psychiatric disorders worldwide. In the present study, effect of water-alcoholic extract of Papaver Rhoeas (L.) on forced swimming test in male and female mice were examined. Male and female swiss-webster mice (20-25g) were used and standard forced swimming test (FTS) was applied. The extract (25, 50 and 100 mg/kg) was injected to the animals 30 min before each session and animals were allowed to swim until they became immobile. Flouxetine (20 mg/kg) was used as standard antidepressant drug. In another groups of animals, 30 min after extract administration, blood samples were taken from retroorbital sinus and centrifuged in 3000 g for 5 min. Plasma samples were used for corticosterone assay. Our experiments showed that the extract is efficient to reduction FST time dose-dependently (P<0.01) regarding to the flouxetine and saline. In addition, corticosterone assay indicated that plasma corticosterone in animals which received extract was higher than flouxetine and saline controls (P<0.001). It is clear that the extract of Papaver Rhoeas (L.) could reduce FTS time better than flouxetine and the effect of the extract may be due to plasma corticosterone increment.

 
Keyword(s): PAPAVER RHOEAS, FLOUXETINE, CORTICOSTERONE, FTS
 
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