Paper Information

Title:  STUDY ON THE ROLE OF L-TYPE CALCIUM CHANNEL BLOCKER DILTIAZEM IN THE ANTICONVULSANT EFFECTS OF CANNABINOID CB1 RECEPTOR AGONIST IN THE PENTYLENETETRAZOLE-INDUCED SEIZURE IN MICE
Type: POSTER
Author(s): MOTIEI LANGEROUD S.M.*,MAZAR ATABAKI A.,NADERI NIMA,MOTAMEDI F.
 
 *NEUROSCIENCE RESEARCH CENTER, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

The cannabinoidergic system plays an important role in modulation of seizure through CB1 receptor. There is also evidence for the role of various types of calcium channels in cannabinoid receptor signaling. In the present study, using pentylenetetrazole (PTZ) model of seizure, the role of an L-type calcium channel blocker (diltiazem) on anticonvulsant effect of a cannabinoid CB1 receptor agonist (ACEA) was investigated. Drugs were administered Intraperitoneally 30 min before PTZ administration. The threshold for clonic PTZ-induced seizures was determined by infusion of a 1% solution of PTZ into the tail vein of unrestricted freely moving mice at a rate of 0.25 ml/min with an infusion pump. A generalized clonic seizure with loss of righting reflex was considered as the endpoint of experiment. Administration of ACEA (2 mg/kg) produced significant increase in the dose of PTZ required for seizure induction compared to control group. There was not significant change in PTZ-induced seizure threshold in any of the groups received various doses of diltiazem alone compared to control group. Coadministration of various doses of diltiazem and ACEA (2 mg/kg) significantly decreased the anticonvulsant effect of ACEA. Based on our results, we suggest that the anticonvulsant effects of cannabinoid CB1 receptor agonists are in part through L-type calcium channels.

 
Keyword(s): DILTIAZEM, ACEA, CANNABINOID, L-TYPE CALCIUM CHANNEL BLOCKER, SEIZURE, PENTYLENETETRAZOLE
 
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